実験室マウスの遺伝的浮動

実験室マウスの遺伝的浮動

原典はJax Laboratoryによる REMEMBER, ONLY YOU CAN PREVENT GENETIC DRIFT

実験室で扱うマウスは遺伝的浮動の発生が不可避であり、実験の再現性を脅かす存在である。

遺伝的浮動のタイムスケール

Through genetic drift, mouse genomes change enough in 20 consecutive inbred generations to be considered substrains of each other. Twenty inbred generations can occur over a course of about five years, which happens quickly in terms of experimental reproducibility. No one wants to be in a situation where what worked in the last grant cycle may not be working now because of drift.

遺伝的浮動による影響を減らすには